Isobutyl chloroformate → 2-Naphthol

HRID 597274

반응식

HRID 597274 반응식
CCCCC[C@H](O)/C=C/[C@@H]1[C@@H:14]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=O)[C:12](=O)[CH:11]=C1.C(OC(Cl)=O)C(C)C>C(N(CC)CC)C>[CH:11]1[C:12]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:19]=[CH:20][C:21]=1[OH:23]

참가 물질

4

반응물 2

HCID 62365Isobutyl chloroformateHCID 5281912Pga1

생성물 1

HCID 86632-Naphthol

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

Following the procedure of Example 1 but using 0.506 g. of PGA1, 0.254 ml. of triethylamine, 0.238 ml. of isobutylchloroformate, and 0.327 g. of β-naphthol, there is obtained a crude residue. This residue is subjected to silica gel chromatography, eluting with ethyl acetate-hexane (2:3) followed by ethyl acetate-hexane (7:3). The residue obtained by concentration of selected fractions, 0.45 g., is crystallized from ethyl acetate diluted with two volumes of hexane as the title compound, white free-flowing crystals, m.p. 49.0°-50.0° C., having Rf 0.5 (TLC on silica gel in ethyl acetate-hexane (1:1)).

출처 및 근거

ORD 기록
ord-6a0d187e852849459f33bce60282529b
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04013693

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