Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylamine → methyl 3-(N-methylsulfamoyl)thiophene-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | 2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester | HCID 2736733 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | methyl 3-(N-methylsulfamoyl)thiophene-2-carboxylate | HCID 12906749 | — |
반응 단계
To a solution of methyl 3-(chlorosulfonyl)thiophene-2-carboxylate (500 mg, 2.077 mmol) in DCM (20 ml), methanamine 2N solution in THF (4.155 ml, 8.31 mmol) was added and the reaction was stirred for 1 hour at RT. The mixture was partitioned between 2N HCl and DCM and the aqueous phase was extracted with DCM. The combined organic layers were dried over sodium sulfate and the solvent was removed affording methyl 3-(N-methylsulfamoyl)thiophene-2-carboxylate (Int. 32) (430 mg, 1.828 mmol, MS/ESI+235.8 [MH]+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09440954B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-9b66d920a79c456da03aea4e17f10758 |
| 출처 메모 | uspto-grants-2016_09 |