Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Chloropropionitrile → 3-(3-Trifluoromethylphenylthio)-propionitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Chloropropionitrile | HCID 10963 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 3-(Trifluoromethyl)benzenethiol | HCID 136751 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-(3-Trifluoromethylphenylthio)-propionitrile | HCID 19843936 | — |
반응 단계
A solution of 15.9 g (0.09 mol) of 3-trifluoromethylthiophenol and 3.8 g (0.095 mol) of sodium hydroxide pellets in 100 ml of water is heated at 65°-70° C and 8.5 g (0.095 mol) of β-chloropropionitrile are added dropwise whilst stirring. The mixture is heated for a quarter of an hour to the reflux temperature and is then cooled and extracted with ether, and the extract is washed with water and dried with magnesium sulphate. This gives 3-(3-trifluoromethylphenylthio)-propionitrile, which is not isolated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04013776 |
| 출처 데이터셋 | uspto-grants-1977_03 |
| ORD ID | ord-56a53ea130574dc8acfa973d562739c3 |
| 출처 메모 | uspto-grants-1977_03 |