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2-(3-Phthalimidopropylthio)oxazole → 2-(3-Aminopropyl)thiooxazole

HRID 597406
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인쇄 미리보기

반응식

HRID 597406 반응식
[H-].NN.C1(=O)[N:8]([CH2:9][CH2:10][CH2:11][S:12][C:13]2[O:14][CH:15]=[CH:16][N:17]=2)C(=O)C2=CC=CC=C12>C(O)C>[NH2:8][CH2:9][CH2:10][CH2:11][S:12][C:13]1[O:14][CH:15]=[CH:16][N:17]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 129234152-(3-Phthalimidopropylthio)oxazoleHCID 86602801Hydrazine monohydride

생성물 1

HCID 205501192-(3-Aminopropyl)thiooxazole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Hydrazine hydride (5.3 g) was added carefully to a solution of 2-(3-phthalimidopropylthio)oxazole (10 g) in ethanol (173 ml) with stirring. The solution was then heated under reflux for 25 minutes. After cooling, and filtration from phthalhydrazide, the filtrate was concentrated under reduced pressure and the residue was re-evaporated with ethanol to yield crude 2-(3-aminopropylthio)oxazole.

후처리

  1. temperatureThe solution was then heated
  2. temperatureunder reflux for 25 minutes
  3. temperatureAfter cooling
  4. filtrationfiltration from phthalhydrazide
  5. concentrationthe filtrate was concentrated under reduced pressure
  6. customthe residue was re-evaporated with ethanol

출처 및 근거

ORD 기록
ord-3fa45082007e4e52a85135c5bbec93de
출처 데이터셋
uspto-grants-1977_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04013769

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