Sodium Methoxide → HCID 70632931, 화합물

HRID 597454노트

반응식

HRID 597454 반응식
[CH3:1][O-:2].[Na+].[C:4]([C:9]1[CH:10]=[C:11]([CH:19]=[CH:20][CH:21]=1)[NH:12][C:13](=[O:18])/[CH:14]=[C:15](\Cl)/[CH3:16])(=[O:8])[CH2:5][CH2:6][CH3:7]>CO>[C:4]([C:9]1[CH:10]=[C:11]([CH:19]=[CH:20][CH:21]=1)[NH:12][C:13](=[O:18])/[CH:14]=[C:15](\[O:2][CH3:1])/[CH3:16])(=[O:8])[CH2:5][CH2:6][CH3:7]

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 86734580HCID 86734580, 화합물

생성물 1

HCID 70632931HCID 70632931, 화합물수율 53.7%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
20 °C

실험 절차

5.4 g of sodium methylate were added with stirring to a mixture of 26.5 g of m-butyryl-3-chlorocrotonanilide and 250 ml of methanol and after stirring for 4 hours at 20° C, the mixture was vacuum filtered to remove sodium chloride. The filtrate was concentrated to dryness under reduced pressure and the residue was chromatographed over silica gel. Elution with a 7-3 mixture of benzene and ethyl acetate yielded 14 g of m-butyryl-3-methoxy-crotonanilide melting at 81° C.

후처리

  1. filtrationfiltered
  2. customto remove sodium chloride
  3. concentrationThe filtrate was concentrated to dryness under reduced pressure
  4. customthe residue was chromatographed over silica gel
  5. washElution
  6. additionwith a 7-3 mixture of benzene and ethyl acetate

출처 및 근거

ORD 기록
ord-9f09840feab349d9a3d7e0f3e9be17d4
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04014679

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