3-Pentanamine → HCID 21445076, 화합물

HRID 597463노트

반응식

HRID 597463 반응식
[CH2:1]([C:5]1[N:10]=[C:9](Cl)[C:8]([N+:12]([O-:14])=[O:13])=[C:7]([Cl:15])[N:6]=1)[CH2:2][CH2:3][CH3:4].[NH2:16][CH:17]([CH2:20][CH3:21])[CH2:18][CH3:19]>C(N(CC)CC)C>[CH2:1]([C:5]1[N:6]=[C:7]([Cl:15])[C:8]([N+:12]([O-:14])=[O:13])=[C:9]([NH:16][CH:17]([CH2:20][CH3:21])[CH2:18][CH3:19])[N:10]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 120193-PentanamineHCID 12280647Pyrimidine, 2-butyl-4,6-dichloro-5-nitro-

생성물 1

HCID 21445076HCID 21445076, 화합물

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

200 ml of alcohol and 4.5 g (44 m-moles) of triethylamine are added to 11 g (44 m-moles) of 2-n-butyl-4,6-dichloro-5-nitro-pyrimidine. At -50° C, 4.0 g (44 m-moles of 3-aminopentane are added dropwise. The reaction mixture is stirred for 3 hours and then evaporated. The residue is suspended in 100 ml of water and extraction is performed with ether. The ethereal extracts are dried over MgSO4 and evaporated to yield 10.5 g of 2-n-butyl-4-chloro-5-nitro-6-(3-pentylamino)-pyrimidine (nD20 : 1.5383) as a yellow oil

후처리

  1. customevaporated
  2. extractionextraction
  3. dry with materialThe ethereal extracts are dried over MgSO4
  4. customevaporated

출처 및 근거

ORD 기록
ord-c56881d8bbf0483d8bf3f8acd467bb9e
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04014677

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