Fenbufen → 7-Phenyl-1-tetralone

HRID 597610

반응식

[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][CH2:15][C:16]([OH:18])=O)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C2C=CC(C(CCC(O)=O)=O)=CC=2)C=CC=CC=1>>[C:1]1([C:7]2[CH:8]=[C:9]3[C:10]([CH2:13][CH2:14][CH2:15][C:16]3=[O:18])=[CH:11][CH:12]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

반응물 2

HCID 3335Fenbufen

HCID 111392304-{[1,1'-Biphenyl]-4-yl}butanoic acid

생성물 1

HCID 37782357-Phenyl-1-tetralone수율 30%

실험 절차

4-(4'-Biphenylyl) butanoic acid (80g, 0.333 mole m.p. 116° C prepared by the Clemmensen reduction of 3-(4'-biphenylcarbonyl) propanoic acid) was cyclized with 85% polyphosphoric acid as described in example 8(a) to give 20.98g (30%) of the tetralone m.p. 67° C after recrystallisation from 40-60 petrol. (Found; C, 86.30; H, 6.53, C16H14O requires; C, 86.45; H, 6.35%).

출처 및 근거

ORD 기록: ord-5a01d01e27cd4ed489b94a510e377d62
출처 데이터셋: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04014907

연결된 노트

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