Triethylamine → 1-ethoxycarbonyloxy-6-chloro1H-benzotriazole

HRID 597692노트

반응식

HRID 597692 반응식
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[OH:7][N:8]1[C:12]2[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=2[N:10]=[N:9]1.C(N(CC)CC)C>C1C=CC=CC=1>[CH2:5]([O:4][C:2]([O:7][N:8]1[C:12]2[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=2[N:10]=[N:9]1)=[O:3])[CH3:6]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 2327116-Chloro-1-hydroxy-1H-benzotriazole

생성물 1

HCID 132928531-ethoxycarbonyloxy-6-chloro1H-benzotriazole수율 45.7%

시약·촉매·용매 1

HCID 241Benzene용매3회

실험 절차

A solution of ethyl chloroformate (2.17 g.) in benzene (10 ml.) was added dropwise to a solution of 1-hydroxy-6-chloro-1H-benzotriazole (3.38 g.) and triethylamine (2.80 ml.) in benzene (30 ml.) under ice-cooling and stirring. Benzene (30 ml.) was further added to the mixture and the reaction temperature was slowly elevated to room temperature the mixture was allowed to stand overnight. Precipitated crystals were filtered off and the filtrate was concentrated. Benzene was added to the residue and an insoluble material was filtered off. The filtrate was concentrated to give 1-ethoxycarbonyloxy-6-chloro1H-benzotriazole (2.2 g.), crystals. The precipitated crystals filtered off and the insoluble material in benzene were mixed and then washed with water, a sodium bicarbonate aqueous solution, 1N hydrochloric acid and water, and recrystallized from methanol (75 ml.) to give the desired compound (3.5 g.), white needles, mp 160° to 162° C.

후처리

  1. temperaturecooling
  2. customwas slowly elevated to room temperature
  3. customPrecipitated crystals
  4. filtrationwere filtered off
  5. concentrationthe filtrate was concentrated
  6. additionBenzene was added to the residue
  7. filtrationan insoluble material was filtered off
  8. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-9d4deea5a1ce4862b6a56f488fac89a3
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04014915

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