Ethanol → HCID 46914009, 화합물

HRID 597845노트

반응식

HRID 597845 반응식
[C:1]([CH2:4][CH2:5][C:6]1[C:14]2[C:13](=[O:15])[CH2:12][CH2:11][CH2:10][C:9]=2[NH:8][CH:7]=1)([OH:3])=[O:2].S(=O)(=O)(O)O.[CH2:21](O)[CH3:22]>>[CH2:21]([O:2][C:1](=[O:3])[CH2:4][CH2:5][C:6]1[C:14]2[C:13](=[O:15])[CH2:12][CH2:11][CH2:10][C:9]=2[NH:8][CH:7]=1)[CH3:22]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 158327213-(4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic acid

생성물 1

HCID 46914009HCID 46914009, 화합물수율 99%

실험 절차

3-Carboxyethyl-4-oxo-4,5,6,7-tetrahydro-1H-indole (3, 52.0 g, 0.251 mol) in ethanol (100 mL) was added with sulfuric acid (1.0 mL). The reaction mixture was heated at reflux for 12 h. The solution was concentrated under reduced pressure and the resultant solids were washed with water (200 mL×2). The solids were air-dried to give 3-(3-ethoxy-3-oxopropyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole (4, 59.0 g, 0.251 mol) as yellow solids in >99% yield.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 12 h
  3. concentrationThe solution was concentrated under reduced pressure
  4. washthe resultant solids were washed with water (200 mL×2)
  5. customThe solids were air-dried

출처 및 근거

ORD 기록
ord-c2e866c8818e4e0d91f3499cf7eebf1d
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897602B2

반응 노트

불러오는 중…