Chloride → Methyl 4-amino-3-nitrobenzoate

HRID 59803

반응식

HRID 59803 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[Cl-].[CH3:15]O>>[CH3:15][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([NH2:1])=[C:3]([N+:11]([O-:13])=[O:12])[CH:4]=1

참가 물질

4

반응물 3

HCID 312ChlorideHCID 887MethanolHCID 74115Benzoic acid, 4-amino-3-nitro-

생성물 1

HCID 3941008Methyl 4-amino-3-nitrobenzoate수율 81%

실험 절차

To a mixture of 4-amino-3-nitro-benzoic acid (10.0 g, 54.9 mmol) suspended in methanol (150 mL) was added thiony chloride (3.99 mL, 54.9 mmol). The mixture was heated to reflux overnight, then cooled to room temperature and filtered. The solid recovered by filtration was rinsed with cold methanol and dried to give 8.68 g (81%) of 4-amino-3-nitro-benzoic acid methyl ester.

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux overnight
  3. filtrationfiltered
  4. filtrationThe solid recovered by filtration
  5. washwas rinsed with cold methanol
  6. customdried

출처 및 근거

ORD 기록
ord-672a1d09152b4116b8e1310c6d95a876
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440956B2

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