3-(2,4-Dimethylphenyl)-1-methyl-5-nitropyridin-2(1H)-one → 5-Amino-3-(2,4-dimethylphenyl)-1-methylpyridin-2(1H)-one
반응식
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:10](=[O:19])[N:11]([CH3:18])[CH:12]=[C:13]([N+:15]([O-])=O)[CH:14]=1.[H][H]>C(O)C.[Pd]>[NH2:15][C:13]1[CH:14]=[C:9]([C:3]2[CH:4]=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=2[CH3:1])[C:10](=[O:19])[N:11]([CH3:18])[CH:12]=1참가 물질
5
실험 절차
To a solution containing 0.17 g (0.66 mmol) of 3-(2,4-dimethylphenyl)-1-methyl-5-nitropyridin-2(1H)-one in 50 ml of ethanol was added 0.10 g of 10% palladium on carbon (Degussa type; 50% wet). The flask was fitted with a balloon of hydrogen and allowed to stir for 5 h. The reaction was filtered through GF/F paper and the filtrate concentrated under reduced pressure to afford 0.063 g (41.9%) of product.
후처리
- filtrationThe reaction was filtered through GF/F paper
- concentrationthe filtrate concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-0f2d926b1a3547e48f4d337bd28e9ca1
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07897607B2
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