methyl 3-(2-chloro-6-fluorophenyl)-2-hydrazinylidene-3-oxopropanoate → Methyl 5-chloro-4-oxo-1,4-dihydrocinnoline-3-carboxylate
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](F)[C:3]=1[C:9](=[O:17])[C:10](=[N:15][NH2:16])[C:11]([O:13][CH3:14])=[O:12]>COCCOCCOCCOC>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[C:9](=[O:17])[C:10]([C:11]([O:13][CH3:14])=[O:12])=[N:15][NH:16]2참가 물질
3
반응 조건
- 온도
- 140 °C
실험 절차
A mixture of 4.2 g (16 mmol) of methyl 3-(2-chloro-6-fluorophenyl)-2-hydrazono-3-oxopropionate in 12 mL of triglyme was heated to 140° C. for 48 h. The slurry was then cooled to room temperature and the precipitate was collected by filtration. The precipitate was washed with diisopropyl ether and dried in vacuo to give 2.55 g (66%) of the title compound as a tan powder.
후처리
- temperatureThe slurry was then cooled to room temperature
- filtrationthe precipitate was collected by filtration
- washThe precipitate was washed with diisopropyl ether
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-a772b97b19494f9aba28cd908cd5b0b6
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07897607B2
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