p-Tolylacetonitrile → 5-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-3-p-tolyl-benzo[c]isoxazole

HRID 59819

반응식

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-])=[O:20])=[CH:15][CH:14]=2)=[CH:11][CH:10]=[N:9]1.[C:22]1([CH3:31])[CH:27]=[CH:26][C:25]([CH2:28]C#N)=[CH:24][CH:23]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]3=[N:19][O:20][C:31]([C:22]4[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=4)=[C:15]3[CH:14]=2)=[CH:11][CH:10]=[N:9]1

참가 물질

반응물 2

HCID 76280p-Tolylacetonitrile

HCID 900327651-(2-fluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole2회

생성물 1

HCID 730526895-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-3-p-tolyl-benzo[c]isoxazole

실험 절차

The title compound, light green solid (92 mg, 71%), MS (ISP) m/z=370.1 [(M+H)−], mp 173° C., was prepared in accordance with the general method of example 1 from 1-(2-fluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate B) (100 mg, 353 μmol) and commercially available 2-(p-tolyl)-acetonitrile.

출처 및 근거

ORD 기록: ord-dfb46334b2b0443c9733d0bcbc9e04d5
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09440962B2

연결된 노트

불러오는 중…