4-Chlorobenzyl cyanide → 3-(4-Chloro-phenyl)-5-[2-(4-fluoro-phenyl)-2H-pyrazol-3-yl]-benzo[c]isoxazole

HRID 59828

반응식

HRID 59828 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=O)=[CH:15][CH:14]=3)=[CH:11][CH:10]=[N:9]2)=[CH:4][CH:3]=1.[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29]C#N)=[CH:25][CH:24]=1>>[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[O:21][N:19]=[C:16]3[CH:15]=[CH:14][C:13]([C:12]4[N:8]([C:5]5[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=5)[N:9]=[CH:10][CH:11]=4)=[CH:18][C:17]=23)=[CH:25][CH:24]=1

참가 물질

3

반응물 2

HCID 2415824-Chlorobenzyl cyanideHCID 900333991-(4-fluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole2회

생성물 1

HCID 730530013-(4-Chloro-phenyl)-5-[2-(4-fluoro-phenyl)-2H-pyrazol-3-yl]-benzo[c]isoxazole

실험 절차

The title compound, yellow solid (81 mg, 59%), MS (ISP) m/z=390.2 [(M+H)+], mp 188° C., was prepared in accordance with the general method of example 1 from 1-(4-fluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate C) (100 mg, 353 μmol) and commercially available 2-(4-chloro-phenyl)-acetonitrile.

출처 및 근거

ORD 기록
ord-08ffc936733049da93c61c32b6a88420
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440962B2

연결된 노트

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