Benzeneacetonitrile, 3-fluoro- → 3-(3-Fluoro-phenyl)-5-[2-(4-methoxy-phenyl)-2H-pyrazol-3-yl]-benzo[c]isoxazole

HRID 59837

반응식

HRID 59837 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-])=[O:21])=[CH:16][CH:15]=3)=[CH:12][CH:11]=[N:10]2)=[CH:5][CH:4]=1.[F:23][C:24]1[CH:25]=[C:26]([CH2:30]C#N)[CH:27]=[CH:28][CH:29]=1>>[F:23][C:24]1[CH:25]=[C:26]([C:30]2[O:21][N:20]=[C:17]3[CH:16]=[CH:15][C:14]([C:13]4[N:9]([C:6]5[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=5)[N:10]=[CH:11][CH:12]=4)=[CH:19][C:18]=23)[CH:27]=[CH:28][CH:29]=1

참가 물질

3

반응물 2

HCID 68145Benzeneacetonitrile, 3-fluoro-HCID 900327501-(4-methoxy-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole2회

생성물 1

HCID 730531513-(3-Fluoro-phenyl)-5-[2-(4-methoxy-phenyl)-2H-pyrazol-3-yl]-benzo[c]isoxazole

실험 절차

The title compound, light green solid (81 mg, 62%), MS (ISP) m/z=386.2 [(M+H)+], mp 203° C., was prepared in accordance with the general method of example 1 from 1-(4-methoxy-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate G) (100 mg, 353 μmol) and commercially available 2-(3-fluoro-phenyl)-acetonitrile.

출처 및 근거

ORD 기록
ord-9de4c69a3f8b409bb9fe1abacbd9c5a7
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440962B2

연결된 노트

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