Benzeneacetonitrile, 3-fluoro- → 5-[2-(4-Chloro-phenyl)-2H-pyrazol-3-yl]-3-(3-fluoro-phenyl)-benzo[c]isoxazole

HRID 59842

반응식

HRID 59842 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=O)=[CH:15][CH:14]=3)=[CH:11][CH:10]=[N:9]2)=[CH:4][CH:3]=1.[F:22][C:23]1[CH:24]=[C:25]([CH2:29]C#N)[CH:26]=[CH:27][CH:28]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:14]=[CH:15][C:16]4=[N:19][O:21][C:29]([C:25]5[CH:26]=[CH:27][CH:28]=[C:23]([F:22])[CH:24]=5)=[C:17]4[CH:18]=3)=[CH:11][CH:10]=[N:9]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 68145Benzeneacetonitrile, 3-fluoro-HCID 90032549HCID 90032549, 화합물2회

생성물 1

HCID 730532945-[2-(4-Chloro-phenyl)-2H-pyrazol-3-yl]-3-(3-fluoro-phenyl)-benzo[c]isoxazole

실험 절차

The title compound, light yellow solid (46 mg, 35%), MS (ISP) m/z=390.2 [(M+H)+], mp 184° C., was prepared in accordance with the general method of example 1 from 1-(4-chloro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate H) (100 mg, 353 μmol) and commercially available 2-(3-fluoro-phenyl)-acetonitrile.

출처 및 근거

ORD 기록
ord-1c45d6a9ea5a4350a634ea5d20f01e7c
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440962B2

연결된 노트

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