p-Tolylacetonitrile → 5-[2-(2,4-Difluoro-phenyl)-2H-pyrazol-3-yl]-3-p-tolyl-benzo[c]isoxazole

HRID 59846

반응식

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:13]([C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=O)=[CH:16][CH:15]=2)=[CH:12][CH:11]=[N:10]1.[C:23]1([CH3:32])[CH:28]=[CH:27][C:26]([CH2:29]C#N)=[CH:25][CH:24]=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:13]([C:14]2[CH:19]=[CH:18][C:17]3=[N:20][O:22][C:32]([C:23]4[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][CH:24]=4)=[C:16]3[CH:15]=2)=[CH:12][CH:11]=[N:10]1

참가 물질

반응물 2

HCID 76280p-Tolylacetonitrile

HCID 900332241-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole2회

생성물 1

HCID 730509555-[2-(2,4-Difluoro-phenyl)-2H-pyrazol-3-yl]-3-p-tolyl-benzo[c]isoxazole

실험 절차

The title compound, light yellow solid (13 mg, 10%), MS (ISP) m/z=388.2 [(M+H)+], mp 147° C., was prepared in accordance with the general method of example 1 from 1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate I) (100 mg, 353 μmol) and commercially available 2-(p-tolyl)-acetonitrile.

출처 및 근거

ORD 기록: ord-3f1c34642f704789aef1248c772f4bca
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09440962B2

연결된 노트

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