4'-Hydroxyacetophenone → 1-[4-(4-Nitrophenoxy)phenyl]ethanone

HRID 598467노트

반응식

F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[OH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18](=[O:20])[CH3:19])=[CH:14][CH:13]=1>>[C:18]([C:15]1[CH:16]=[CH:17][C:12]([O:11][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)=[CH:13][CH:14]=1)(=[O:20])[CH3:19]

참가 물질

반응물 2

HCID 74694'-Hydroxyacetophenone

HCID 9590p-Fluoronitrobenzene

생성물 1

HCID 2386041-[4-(4-Nitrophenoxy)phenyl]ethanone

실험 절차

Entry 10: 4-Fluoro-1-nitrobenzene and p-hydroxyacetophenone were reacted according to Method A13, Step 1 to afford the 4-(4-acetylphenoxy)-1-nitrobenzene. 4-(4-Acetylphenoxy)-1-nitrobenzene was reduced according to Method A13, Step 4 to afford 4-(4-acetylphenoxy)aniline. According to Method C3, 5-(trifluoromethyl)-2-methoxybutylaniline was reacted with bis(trichloromethyl) carbonate followed by 4-(4-acetylphenoxy)aniline to afford the urea.

출처 및 근거

ORD 기록: ord-2d9bdb9e8c96495d8a43c896c4495843
출처 데이터셋: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07897623B2

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