Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 4-Chloropyridine-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 4-Chloropyridine-2-carbonyl chloride--hydrogen chloride (1/1) | HCID 22397270 | — |
| 생성물 | 4-Chloropyridine-2-carboxamide | HCID 303543 | — |
반응 단계
Entry 12: 4-Chloropyridine-2-carbonyl chloride HCl salt was reacted with ammonia according to Method A2, Step 3b to form 4-chloro-2-pyridinecarboxamide. 4-Chloro-2-pyridinecarboxamide was reacted with 3-aminophenol according to Method A2, Step 4 using DISC in place of DMF to give 3-(2-carbamoyl-4-pyridyloxy)aniline. According to Method C2a, 2-methoxy-5-(trifluoromethyl)aniline was reacted with phosgene followed by 3-(2-carbamoyl-4-pyridyloxy)aniline to afford the urea.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07897623B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-c7bb6184cdb34dbeb8de7a26b85bc6fe |
| 출처 메모 | uspto-grants-2011_03 |