Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminomethyl-1-ethylpyrrolidine → 3-(4-Nitrophenoxy)benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminomethyl-1-ethylpyrrolidine | HCID 117295 | — |
| 반응물 | 3-(4-Nitrophenoxy)benzoic acid | HCID 767919 | — |
| 생성물 | 3-(4-Nitrophenoxy)benzoic acid | HCID 767919 | — |
| 생성물 | 4-(3-(N-((1-methylpyrrolidinyl)methyl)carbamoyl)phenoxy)-1-nitrobenzene | HCID 23614564 | — |
반응 단계
Entry 64: 4-(3-Carboxyphenoxy)-1-nitrobenzene was synthesized according to Method A13, Step 2. 4-(3-Carboxyphenoxy)-1-nitrobenzene was coupled with 2-aminomethyl-1-ethylpyrrolidine according to Method A13, Step 3 to give 4-(3-(N-((1-methylpyrrolidinyl)methyl)carbamoyl)phenoxy)-1-nitrobenzene. According to Method A13 Step 4,4-(3-(N-((1-methylpyrrolidinyl)methyl)carbamoyl)phenoxy)-1-nitrobenzene was reduced to 4-(3-(N-((1-methylpyrrolidinyl)methyl)carbamoyl)phenoxy)aniline. According to Method C1a, 4-chloro-3-(trifluoromethyl)phenyl isocyanate was reacted with 4-(3-(N-((1-methylpyrrolidinyl)methyl)carbamoyl)phenoxy)aniline to afford the urea.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07897623B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-0f8935ce7f9a4ca18801a4bb1ccc2f8c |
| 출처 메모 | uspto-grants-2011_03 |