Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (7-Chloro-quinazolin-2-yl)-piperidin-3-yl-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1-BOC-3-Aminopiperidine | HCID 545809 | — |
| 반응물 | 2,7-Dichloroquinazoline | HCID 12413929 | — |
| 반응물 | (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-yl-amine | HCID 57748894 | — |
| 생성물 | (7-Chloro-quinazolin-2-yl)-piperidin-3-yl-amine | HCID 57748966 | — |
반응 단계
In analogy to the procedure described for the synthesis of (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-yl-amine; hydrochloride (example 1, step 1) the title compound was prepared from 2,7-dichloro-quinazoline (Synthesis 1978, 5, 379-82) and 3-Amino-piperidine-1-carboxylic acid tert-butyl ester (commercially available) and subsequent cleavage of the tert-butyl oxy carbonyl protecting group under acidic conditions. (MH+) 263.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07897627B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-b52b91ea5590466395e053fadafa4283 |
| 출처 메모 | uspto-grants-2011_03 |