2-Methyl-5-(4-fluorophenyl)thiazole-4-carbonyl chloride → HCID 23146331, 화합물

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([CH3:13])=[N:10][C:9]=2[C:14](Cl)=[O:15])=[CH:4][CH:3]=1.[O:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[C:18]1[C:26]([CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][NH:29]1)=[O:27]>>[O:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[C:18]1[C:26]([CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][N:29]1[C:14]([C:9]1[N:10]=[C:11]([CH3:13])[S:12][C:8]=1[C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)=[O:15])=[O:27]

참가 물질

반응물 2

HCID 223241192-Methyl-5-(4-fluorophenyl)thiazole-4-carbonyl chloride

HCID 23146318HCID 23146318, 화합물

생성물 1

HCID 23146331HCID 23146331, 화합물

실험 절차

The title compound was prepared, using the method of Example 1, from 5-(4-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl chloride (0.1 g, 0.39 mmol) and (RS)-1-benzofuran-2-yl-1-piperidin-2-yl-methanone, D9 (0.1 g, 0.43 mmol) as a colourless solid (0.074 g, 43%)

출처 및 근거

ORD 기록: ord-57c5539d979946198909d3220c0f9b49
출처 데이터셋: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07897618B2

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