Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → 4-(4-Nitropyridin-2-yl)morpholine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 4-Nitropyridine | HCID 70734 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(4-Nitropyridin-2-yl)morpholine | HCID 57418546 | 56.5% |
반응 단계
To a solution of 2-chloro, 4-nitropyridine (0.2 g, 1.27 mmol) in THF (3 mL) was added morpholine (328 mg, 38.1 mmol). The reaction was heated to 80 C and stirred overnight. The solvent was evaporated and the residue purified by column chromatography (2/1 Hex/EtOAc) to yield 150 mg of the target compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07897599B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-e456b857d97c47feae59f8a0e57888c7 |
| 출처 메모 | uspto-grants-2011_03 |