2-Aminothiazole → 2-(2-Isopropoxyphenoxy)-1-nitrobenzene

HRID 598937

반응식

HRID 598937 반응식
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11])([CH3:3])[CH3:2].F[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N+:19]([O-:21])=[O:20].[CH3:22][O:23]C1C=CC=CC=1OC1C=CC=CC=1N.[CH:38]([O:41][C:42]1[CH:55]=[CH:54][CH:53]=[CH:52][C:43]=1[O:44][C:45]1[CH:51]=[CH:50][CH:49]=[CH:48][C:46]=1[NH2:47])([CH3:40])[CH3:39].[NH2:56][C:57]1[S:58][CH:59]=[CH:60][N:61]=1>>[CH:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N+:19]([O-:21])=[O:20])([CH3:3])[CH3:2].[CH:38]([O:41][C:42]1[CH:55]=[CH:54][CH:53]=[CH:52][C:43]=1[O:44][C:45]1[CH:51]=[CH:50][CH:49]=[CH:48][C:46]=1[NH:47][C:22]([NH:56][C:57]1[S:58][CH:59]=[CH:60][N:61]=1)=[O:23])([CH3:40])[CH3:39]

참가 물질

7

반응물 5

HCID 21552-AminothiazoleHCID 209492-IsopropoxyphenolHCID 738951-Fluoro-2-nitrobenzeneHCID 2541442-(2-Methoxyphenoxy)anilineHCID 669989852-(2-Isopropoxyphenoxy)aniline

생성물 2

HCID 59732946N-[2-(2-Isopropoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea수율 65%HCID 669989202-(2-Isopropoxyphenoxy)-1-nitrobenzene수율 69%

실험 절차

2-(2-Isopropoxyphenoxy)-1-nitrobenzene (0.90 g, 69%) was prepared from 2-iso-propoxyphenol (0.84 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2-methoxyphenoxy)aniline (0.65 g, 81%) following general procedure B. N-[2-(2-Isopropoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (120 mg, 65%) was prepared from 2-(2-isopropoxyphenoxy)aniline (122 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

출처 및 근거

ORD 기록
ord-101fa8ba03f948f59e6e57185a60cc22
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897628B2

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