Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 2-(2,3-Dimethoxyphenoxy)-5-fluoro-1-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| 반응물 | 2,3-Dimethoxyphenol | HCID 78828 | — |
| 반응물 | 2-(2,3-Dimethoxyphenoxy)-5-fluoroaniline | HCID 66998831 | — |
| 생성물 | N-[2-(2,3-Dimethoxyphenoxy)-5-fluorophenyl]-N'-(thiazol-2-yl)urea | HCID 59733076 | 65% |
| 생성물 | 2-(2,3-Dimethoxyphenoxy)-5-fluoro-1-nitrobenzene | HCID 66999058 | 68% |
반응 단계
2-(2,3-Dimethoxyphenoxy)-5-fluoro-1-nitrobenzene (1.0 g, 68%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 2,5-difluoro-1-nitrobenzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2,3-dimethoxyphenoxy)-5-fluoroaniline (0.67 g, 75%) following general procedure C. N-[2-(2,3-Dimethoxyphenoxy)-5-fluorophenyl]-N′-(thiazol-2-yl)urea (126 g, 65%) was prepared from 2-(2,3-dimethoxyphenoxy)-5-fluoroaniline (132 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07897628B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-0314c367c63f437788cd7a8e8ad6303d |
| 출처 메모 | uspto-grants-2011_03 |