Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 5-Fluoro-2-(2-trifluromethylphenoxy)-1-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| 반응물 | 2-Trifluoromethylphenol | HCID 67958 | — |
| 반응물 | 2-(2-Trifluoromethylphenoxy)-5-fluoroaniline | HCID 28412097 | — |
| 생성물 | n-[5-Fluoro-2-(2-trifluoromethylphenoxy)phenyl]-n'-(thiazol-2-yl)urea | HCID 59732964 | 74% |
| 생성물 | 5-Fluoro-2-(2-trifluromethylphenoxy)-1-nitrobenzene | HCID 66998992 | 78% |
반응 단계
5-Fluoro-2-(2-trifluoromethylphenoxy)-1-nitrobenzene (1.17 g, 78%) was prepared from 2-hydroxybenzotrifluoride (0.89 g, 5.5 mmol) and 2,5-difluoro-1-nitrobenzene (0.8 g, 5.0 mmol) following the general procedure A. This compound was reduced to 5-fluoro-2-(2-trifluoromethylphenoxy)-aniline (0.65 g, 62%) following the general procedure B. N-[5-Fluoro-2-(2-trifluoromethylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (146 mg, 74%) was prepared from 2-(2-trifluoromethylphenoxy)-5-fluoroaniline (135 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07897628B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-70714b9f684b4631a985f8ea0bd065ab |
| 출처 메모 | uspto-grants-2011_03 |