Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 2-(2,4-Difluorophenylsulfanyl)-1-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 반응물 | 2,4-Difluorobenzene-1-thiol | HCID 2737073 | — |
| 반응물 | 2-(2,4-Difluorophenylsulfanyl)aniline | HCID 43345446 | — |
| 생성물 | 2-(2,4-Difluorophenylsulfanyl)-1-nitrobenzene | HCID 52479353 | 78% |
| 생성물 | 1-[2-(2,4-Difluorophenylsulfanyl)phenyl]-3-(thiazol-2-yl)urea | HCID 59732885 | 72% |
반응 단계
2-(2,4-Difluorophenylsulfanyl)-1-nitrobenzene (1.04 g, 78%) was prepared from 2,4-difluorothiophenol (0.73 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2,4-difluorophenylsulfanyl)-aniline (0.64 g, 70%) following the general procedure B. 1-[2-(2,4-Difluorophenylsulfanyl)-phenyl]-3-(thiazol-2-yl)urea (130 g, 72%) was prepared from 2-(2,4-difluorophenylsulfanyl)-aniline (118 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07897628B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-4df6a88b0dbb4fba869cd33075da49b9 |
| 출처 메모 | uspto-grants-2011_03 |