2-Aminothiazole → Methyl 2-(2-nitrophenylthio)benzoate

HRID 598979

반응식

HRID 598979 반응식
[C:1]([O:10][CH3:11])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[SH:4].F[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N+:19]([O-:21])=[O:20].[CH3:22][O:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[S:32][C:33]1[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=1[NH2:35])=[O:25].[NH2:40][C:41]1[S:42][CH:43]=[CH:44][N:45]=1>>[CH3:11][O:10][C:1]([C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[S:4][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N+:19]([O-:21])=[O:20])=[O:9].[CH3:22][O:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[S:32][C:33]1[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=1[NH:35][C:1]([NH:40][C:41]1[S:42][CH:43]=[CH:44][N:45]=1)=[O:9])=[O:25]

참가 물질

6

반응물 4

HCID 21552-AminothiazoleHCID 21009Benzoic acid, 2-mercapto-, methyl esterHCID 738951-Fluoro-2-nitrobenzeneHCID 614949Methyl 2-[(2-aminophenyl)sulfanyl]benzoate2회

생성물 2

HCID 57362693Methyl 2-(2-nitrophenylthio)benzoate수율 80%HCID 59733061N-[2-(2-Methoxycarbonylphenylsulfanyl)phenyl]-N'-(thiazol-2-yl)urea수율 74%

실험 절차

2-(2-Methoxycarbonylphenylsulfanyl)nitrobenzene (1.15 g, 80%) was prepared from methyl thiosalicylate (0.92 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2-methoxycarbonylphenylsulfanyl)aniline (0.75 g, 73%) following the general procedure B. N-[2-(2-Methoxycarbonylphenylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea (142 mg, 74%) was prepared from 2-(2-methoxycarbonylphenylsulfanyl)aniline (130 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

출처 및 근거

ORD 기록
ord-35a733a6bdfc401cb13c65f529748bf3
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897628B2

연결된 노트

불러오는 중…