Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 2-[4-Fluoro-2-(3-thiazol-2-yl-ureido)-phenoxy]-6-methoxybenzoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| 반응물 | Methyl 2-hydroxy-6-methoxybenzoate | HCID 527092 | — |
| 반응물 | 2-(2-Amino-4-fluoro-phenoxy)-6-methoxy-benzoic acid methyl ester | HCID 66999207 | — |
| 생성물 | 2-[4-Fluoro-2-(3-thiazol-2-yl-ureido)-phenoxy]-6-methoxybenzoic acid methyl ester | HCID 59732977 | 62% |
| 생성물 | 2-(4-Fluoro-2-nitro-phenoxy)-6-methoxy-benzoic acid methyl ester | HCID 66998457 | 58% |
반응 단계
2-(4-Fluoro-2-nitro-phenoxy)-6-methoxy-benzoic acid methyl ester (0.94 g, 58%) was prepared from 2-hydroxy-6-methoxy-benzoic acid methyl ester (1.01 g, 5.5 mmol) and 2,5-difluoro-1-nitro-benzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2-amino-4-fluoro-phenoxy)-6-methoxy-benzoic acid methyl ester (0.51 g, 60%) following general procedure C. 2-[4-Fluoro-2-(3-thiazol-2-yl-ureido)-phenoxy]-6-methoxy-benzoic acid methyl ester (129 mg, 62%) was prepared from 2-(2-amino-4-fluoro-phenoxy)-6-methoxy-benzoic acid methyl ester (145 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07897628B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-f44bc77e783d40ed9bf2c334f2e78f79 |
| 출처 메모 | uspto-grants-2011_03 |