Ammonia → Benzo[b]thiophene-2-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

반응식

[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[CH:13]1[CH:18]=[C:17]2[CH:19]=[C:20]([C:22](O)=[O:23])[S:21][C:16]2=[CH:15][CH:14]=1.N>>[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@@H:5]3[NH:12][C:22]([C:20]3[S:21][C:16]4[CH:15]=[CH:14][CH:13]=[CH:18][C:17]=4[CH:19]=3)=[O:23])[CH2:3]1)[CH2:9]2

참가 물질

반응물 3

HCID 222Ammonia

HCID 95864Benzo(b)thiophene-2-carboxylic acid

HCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

생성물 1

HCID 67152120Benzo[b]thiophene-2-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

실험 절차

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and thianaphthene-2-carboxylic acid (Aldrich) according to methods A and C; yield 57 mg, 0.16 mmol (50%): 1H NMR (300 MHz, methanol-d4) δ 1.98 (d, J=13 Hz, 2H), 2.20 (s, 1H), 2.36 (d, J=14 Hz, 2H), 2.49 (s, 2H), 3.57 (s, 2H), 3.67 (d, J=2 Hz, 4H), 4.42 (s, 1H), 7.39-7.50 (m, 2H), 7.88-7.96 (m, 2H), 8.12 (s, 1H); MS (DCI/NH3) m/z 313 (M+H)+; Anal. C18H20N2OS.HCl 0.12H2O: C, H, N.