Ammonia → 1H-Indole-6-carboxylic acid(4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

HRID 599200

반응식

HRID 599200 반응식
[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[NH:13]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([C:22](O)=[O:23])[CH:20]=2)[CH:15]=[CH:14]1.N>>[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@@H:5]3[NH:12][C:22]([C:19]3[CH:20]=[C:21]4[C:16]([CH:15]=[CH:14][NH:13]4)=[CH:17][CH:18]=3)=[O:23])[CH2:3]1)[CH2:9]2

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 5952301H-indole-6-carboxylic acidHCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

생성물 1

HCID 671522071H-Indole-6-carboxylic acid(4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

실험 절차

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and indole-6-carboxylic acid (Lancaster) according to methods A and C; yield 91 mg, 0.25 mmol (69%): 1H NMR (300 MHz, methanol-d4) δ 1.98 (d, J=13 Hz, 2H), 2.21 (s, 1H), 2.36 (d, J=13 Hz, 2H), 2.49 (s, 2H), 3.58 (s, 2H), 3.69 (s, 4H), 4.42 (s, 1H), 6.52 (dd, J=3, 1 Hz, 1H), 7.41 (d, J=3 Hz, 1H), 7.52 (dd, J=8, 2 Hz, 1H), 7.63 (dd, J=8, 1 Hz, 1H), 7.93-7.99 (m, 1H); MS (DCI/NH3) m/z 296 (M+H)+; Anal. C18H21N3O.HCl.1.1H2O.0.2C4H8O2: C, H, N.

출처 및 근거

ORD 기록
ord-d6c4a3b83a5144eda1b41b4f6ecd8195
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897766B2

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