Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 5-Phenylthiophene-2-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 5-Phenyl-2-Thiophenecarboxylic Acid | HCID 736494 | — |
| 반응물 | 1-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride | HCID 67152122 | — |
| 생성물 | 5-Phenylthiophene-2-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride | HCID 67152107 | — |
반응 단계
Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 5-phenylthiophene-2-carboxylic acid (Maybridge) according to methods A and C; yield 67 mg, 0.18 mmol (82%): 1H NMR (300 MHz, methanol-d4) δ 1.97 (d, J=14 Hz, 2H), 2.20 (s, 1H), 2.33 (d, J=14 Hz, 2H), 2.48 (s, 2H), 3.57 (s, 2H), 3.67 (d, J=2 Hz, 4H), 4.39 (s, 1H), 7.32-7.47 (m, 4H), 7.66-7.72 (m, 2H), 7.83 (d, J=4 Hz, 1H); MS (DCI/NH3) m/z 339 (M+H)+; Anal. C20H22N2OS.HCl: C, H, N.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07897766B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-fdf362e12fa94cfa916998c4f51ac732 |
| 출처 메모 | uspto-grants-2011_03 |