Ammonia → 2,2'-Bithiophene-5-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

HRID 599216

반응식

HRID 599216 반응식
[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[S:13]1[C:17]([C:18](O)=[O:19])=[CH:16][CH:15]=[C:14]1[C:21]1[S:22][CH:23]=[CH:24][CH:25]=1.N>>[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH:12][C:18]([C:17]3[S:13][C:14]([C:21]4[S:22][CH:23]=[CH:24][CH:25]=4)=[CH:15][CH:16]=3)=[O:19])[CH2:3]1)[CH2:9]2

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 1509652,2'-Bithiophene-5-carboxylic acidHCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

생성물 1

HCID 671521142,2'-Bithiophene-5-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride

실험 절차

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 2,2′-bithiophene-5-carboxylic acid (Acros) according to methods A and C; yield 142 mg, 0.37 mmol (93%): 1H NMR (300 MHz, methanol-d4) δ 2.06-2.27 (m, 5H), 2.46 (s, 2H), 3.49 (d, J=13 Hz, 2H), 3.55 (s, 2H), 3.82 (d, J=13 Hz, 2H), 4.24 (s, 1H), 7.08 (dd, J=5, 4 Hz, 1H), 7.24 (d, J=4 Hz, 1H), 7.35 (dd, J=4, 1 Hz, 1H), 7.43 (dd, J=5, 1 Hz, 1H), 7.79 (d, J=4 Hz, 1H); MS (DCI/NH3) m/z 345 (M+H)+; Anal. C18H20N2OS2.HCl: C, H, N.

출처 및 근거

ORD 기록
ord-16f2069f1660441b87826f981f0b01d3
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897766B2

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