Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 599287생성일: 2026년 10월 26일
(6-Chloro-4-(methylamino)pyridin-3-yl)methanol → 6-Chloro-4-(methylamino)nicotinaldehyde
https://huagongshe.com/reaction/599287
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | (6-Chloro-4-(methylamino)pyridin-3-yl)methanol | HCID 51000240 | — |
| 촉매 | Manganese dioxide | HCID 14801 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 6-Chloro-4-(methylamino)nicotinaldehyde | HCID 23434571 | 87.8% |
반응 단계
A mixture of (6-chloro-4-(methylamino)pyridin-3-yl)methanol (2.9 g, 16.7 mmol) and MnO2 (11.7 g, 133.6 mmol) in anhydrous DCM (25 mL) was stirred at 30° C. for 6 h. The reaction mixture was cooled to RT, filtered and concentrated in vacuo to give 6-chloro-4-(methylamino)nicotinaldehyde (2.5 g, 87% yield). 1H NMR (400 MHz, DMSO-d6): δ 9.83 (s, 1H), 8.52 (br s, 1 H), 8.40 (s, 1 H), 6.75 (s, 1 H), 2.87 (d, J=5.8 Hz, 3 H); MS (ESI) m/z: 171.0 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07897762B2 |
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| 출처 데이터셋 | uspto-grants-2011_03 |
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| ORD ID | ord-7cd0aa942d55465f912538914b926d77 |
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| 출처 메모 | uspto-grants-2011_03 |
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