Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine → 4-Amino-3-fluoro-5-iodobenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | 4-Amino-3-fluorobenzonitrile | HCID 2756431 | — |
| 촉매 | Silver sulfate | HCID 159865 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-Amino-3-fluoro-5-iodobenzonitrile | HCID 44203120 | — |
반응 단계
A mixture of 4-amino-3-fluorobenzonitrile (147 mmol), I2 (147 mmol) and Ag2SO4 (147 mmol) in EtOH (700 mL) was stirred at room temperature for 1.5 h. The mixture was filtered and concentrated. The residue was dissolved in EtOAc and washed (sat. Na2S2O3×3). The organic layer was dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (SiO2, 95:5 to 70:30 cyclohexane/EtOAc) to yield the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09440929B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-0440163263d74d16a1464a8da506aac9 |
| 출처 메모 | uspto-grants-2016_09 |