참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 2-Bromo-4-methyl-5-nitropyridine | HCID 345873 | — |
| 촉매 | Iron | HCID 23925 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-Bromo-4-methylpyridin-3-amine | HCID 19926094 | — |
반응 단계
A mixture of NH4Cl (14.9 mmol) and iron powder (18.4 mmol) in H2O (5 mL) was stirred at 90° C. 2-bromo-4-methyl-5-nitropyridine (2.3 mmol) was added in portions. The mixture was stirred at 90° C. for 1 h and 15 min. The reaction was stopped and extracted with EtOAc. The organic layer was dried (Na2SO4) and concentrated to yield the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09440929B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-25b06232104b4fb280ad8f917456b77e |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
