Ammonium Chloride → 6-Bromo-4-methylpyridin-3-amine

HRID 59940

반응식

HRID 59940 반응식
[NH4+].[Cl-].[Br:3][C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([N+:11]([O-])=O)=[CH:6][N:5]=1>O.[Fe]>[Br:3][C:4]1[N:5]=[CH:6][C:7]([NH2:11])=[C:8]([CH3:10])[CH:9]=1

참가 물질

5

반응물 2

HCID 25517Ammonium ChlorideHCID 3458732-Bromo-4-methyl-5-nitropyridine

생성물 1

HCID 199260946-Bromo-4-methylpyridin-3-amine

시약·촉매·용매 2

HCID 23925Iron촉매HCID 962Water용매

반응 조건

온도
90 °C

실험 절차

A mixture of NH4Cl (14.9 mmol) and iron powder (18.4 mmol) in H2O (5 mL) was stirred at 90° C. 2-bromo-4-methyl-5-nitropyridine (2.3 mmol) was added in portions. The mixture was stirred at 90° C. for 1 h and 15 min. The reaction was stopped and extracted with EtOAc. The organic layer was dried (Na2SO4) and concentrated to yield the desired product.

후처리

  1. stirringThe mixture was stirred at 90° C. for 1 h and 15 min
  2. extractionextracted with EtOAc
  3. dry with materialThe organic layer was dried (Na2SO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-25b06232104b4fb280ad8f917456b77e
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440929B2

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