참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chlorosuccinimide | HCID 31398 | — |
| 반응물 | 4-Amino-3-fluorobenzonitrile | HCID 2756431 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 4-Amino-3-chloro-5-fluorobenzonitrile | HCID 68039995 | — |
반응 단계
A mixture of 4-amino-3-fluorobenzonitrile (184 mmol) and NCS (276 mmol) in AcOH (300 mL) was stirred at 70° C. for approximately 16 h. The mixture was concentrated. H2O was added to the residue and the solid product was filtered off and washed (sat. NaHCO3 and H2O). To eliminate H2O, THF was added and removed under reduced pressure to yield the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09440929B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-306095c73a9a4bfabc97bcd9d3ba38ab |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
