Sulfuric Acid → HCID 68322517, 화합물

HRID 59942노트

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HRID 59942 반응식
OS(O)(=O)=O.N[C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][C:8]=1[CH2:15][CH3:16].N([O-])=[O:18].[Na+]>O>[CH2:15]([C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][C:7]=1[OH:18])[C:11]#[N:12])[CH3:16]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 27353304-Amino-3-ethylbenzonitrileHCID 23668193Sodium Nitrite

생성물 1

HCID 68322517HCID 68322517, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
100 °C

실험 절차

Concentrated H2SO4 (3.4 mL) was added dropwise to a solution of 4-amino-3-ethylbenzonitrile (6.84 mmol) in H2O (12 mL) at 0° C. A solution of NaNO2 (7.52 mmol) in H2O (5 mL) was added dropwise at 0° C. to the resulting mixture. The reaction was stirred at 0° C. for 30 min and at 100° C. for 2 h. The mixture was cooled to room temperature and extracted with EtOAc. The organic layer was washed (H2O), dried and concentrated to yield the desired product.

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. extractionextracted with EtOAc
  3. washThe organic layer was washed (H2O)
  4. customdried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-33b4df3f08864a06bc6dd8ba3ccfe5e1
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440929B2

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