Triethylamine → 5-[4-(3,5-Di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-furan-2-carboxylic acid methyl ester

HRID 599480노트

반응식

HRID 599480 반응식
Cl.[C:2]([C:6]1[CH:11]=[C:10]([S:12][CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH:9]=[C:8]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:7]=1[OH:23])([CH3:5])([CH3:4])[CH3:3].C(N(CC)CC)C.[CH3:31][O:32][C:33]([C:35]1[O:36][C:37]([S:40](Cl)(=[O:42])=[O:41])=[CH:38][CH:39]=1)=[O:34]>ClCCl>[CH3:31][O:32][C:33]([C:35]1[O:36][C:37]([S:40]([N:16]2[CH2:17][CH2:18][CH:13]([S:12][C:10]3[CH:9]=[C:8]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:7]([OH:23])=[C:6]([C:2]([CH3:5])([CH3:4])[CH3:3])[CH:11]=3)[CH2:14][CH2:15]2)(=[O:42])=[O:41])=[CH:38][CH:39]=1)=[O:34]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 2736845Methyl 5-(Chlorosulfonyl)-2-FuroateHCID 86635427HCID 86635427, 화합물

생성물 1

HCID 866354335-[4-(3,5-Di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-furan-2-carboxylic acid methyl ester수율 74.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 2,6-di-tert-butyl-4-(piperidin-4-ylsulfanyl)-phenol hydrochloride (Ex. 3c, 280 mg, 0.78 mmol) in 5 mL of dichloromethane was added triethylamine (240 mg, 2.37 mmol). The mixture was stirred for 3 min followed by the addition of 5-chlorosulfonyl-furan-2-carboxylic acid methyl ester (210 mg, 0.94 mmol). The stirring was continued for 2 h at room temperature and then the reaction was quenched with 20 mL of saturated NaH2PO4. The mixture was extracted with Ethyl acetate (40 mL) and the organic phase was dried over Na2SO4 and concentrated under reduced pressure. Chromatography (3-50% Ethyl acetate/hexanes) gave 5-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-furan-2-carboxylic acid methyl ester as a clear oil (295 mg, 74%). ESI/CI-MS m/z 508 ([M−H]−).

후처리

  1. waitThe stirring was continued for 2 h at room temperature
  2. customthe reaction was quenched with 20 mL of saturated NaH2PO4
  3. extractionThe mixture was extracted with Ethyl acetate (40 mL)
  4. dry with materialthe organic phase was dried over Na2SO4
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-77fe4c6fb40a48fdb3f88474610503a3
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897776B2

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