Ethanol → HCID 178470113, 화합물

HRID 599487

반응식

HRID 599487 반응식
[SH:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1.OS(O)(=O)=O.[CH2:15](O)[CH3:16]>>[SH:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([O:9][CH2:15][CH3:16])=[O:8])[N:6]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 178524840HCID 178524840, 화합물

생성물 1

HCID 178470113HCID 178470113, 화합물

실험 절차

To 2-mercaptothiazole-4-carboxylic acid (Ex. 19b, 4.2 g) in 50 mL ethyl alcohol was added 2 mL conc. H2SO4. The mixture was heated to reflux for 8 h and cooled. The solvent was removed under reduced pressure and the residue was poured onto 50 mL ice water. The solid was collected, washed with water and dried under vacuum. The crude product was recrystallized from 8 mL ethyl alcohol to afford ethyl 2-mercaptothiazole-4-carboxylate (2.3 g) as a yellow solid.

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 8 h
  3. temperaturecooled
  4. customThe solvent was removed under reduced pressure
  5. additionthe residue was poured onto 50 mL ice water
  6. customThe solid was collected
  7. washwashed with water
  8. customdried under vacuum
  9. customThe crude product was recrystallized from 8 mL ethyl alcohol

출처 및 근거

ORD 기록
ord-fb23ee1e14b8406a83273c164f96a2e1
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897776B2

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