Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Urea → 4-Oxo-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Urea | HCID 1176 | — |
| 반응물 | Ethyl orthoformate | HCID 31214 | — |
| 반응물 | Dimethyl 3-oxoglutarate | HCID 74591 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 4-Oxo-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester | HCID 11390199 | 82.3% |
반응 단계
A mixture of dimethyl 3-oxopentanedioate (12 g, 69 mmol), CH(OEt)3 (15.1 g, 100 mmol) and urea (6 g, 100 mmol) in xylene (25 mL) was heated to reflux for 3 hours. The mixture was cooled to room temperature and the precipitate was filtered, washed with xylene and DCM to afford the title compound as white solid (yield 82.3%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09440968B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-b7e52f2fac1f4af8908e41e0da758d72 |
| 출처 메모 | uspto-grants-2016_09 |