3-(Trifluoromethyl)benzylamine → 4-(3-Trifluoromethyl-benzylamino)-benzo[d][1,2,3]triazine-8-carboxamide

HRID 59960

반응식

HRID 59960 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][NH2:7].O[C:14]1[C:15]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([NH2:26])=[O:25])[C:16]=2[N:17]=[N:18][N:19]=1>>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][NH:7][C:14]1[C:15]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([NH2:26])=[O:25])[C:16]=2[N:17]=[N:18][N:19]=1

참가 물질

3

반응물 2

HCID 759623-(Trifluoromethyl)benzylamineHCID 1785136134-oxo-1H-1,2,3-benzotriazine-8-carboxamide

생성물 1

HCID 901941184-(3-Trifluoromethyl-benzylamino)-benzo[d][1,2,3]triazine-8-carboxamide

실험 절차

Compound 1 was prepared following general synthetic scheme 7 wherein 3-trifluoromethyl-benzylamine was reacted with 4-hydroxybenzo[d][1,2,3]triazine-8-carboxamide to give the title compound. LC-MS [348 (M+1)], 1HNMR (400 MHz, DMSO-d6): δ 9.36-9.33 (m, 2H), 8.55-8.49 (m, 2H), 8.04 (s, 1H), 8.02-7.98 (m, 1H), 7.80 (s, 1H), 7.72 (d, 1H), 7.64 (d, 1H), 7.59-7.56 (m, 1H), 5.00 (d, 2H).

후처리

  1. customCompound 1 was prepared

출처 및 근거

ORD 기록
ord-105f98a2d454481381d761f49a77989b
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440968B2

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