4-(Trifluoromethyl)benzylamine → 4-((4-(Trifluoromethyl)benzyl)amino)benzo[d][1,2,3]triazine-8-carboxamide

HRID 59967노트

반응식

HRID 59967 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH2:10])=[CH:5][CH:4]=1.O[C:14]1[C:15]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([NH2:26])=[O:25])[C:16]=2[N:17]=[N:18][N:19]=1>>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:4]=[CH:5][C:6]([CH2:9][NH:10][C:14]2[C:15]3[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([NH2:26])=[O:25])[C:16]=3[N:17]=[N:18][N:19]=2)=[CH:7][CH:8]=1

참가 물질

3

반응물 2

HCID 768044-(Trifluoromethyl)benzylamineHCID 1785136134-oxo-1H-1,2,3-benzotriazine-8-carboxamide

생성물 1

HCID 760735794-((4-(Trifluoromethyl)benzyl)amino)benzo[d][1,2,3]triazine-8-carboxamide

실험 절차

Compound 8 was prepared following general synthetic scheme 7 wherein (4-(trifluoromethyl)phenyl)methanamine was reacted with 4-hydroxybenzo[d][1,2,3]-triazine-8-carboxamide to give the title compound. LC-MS [348 (M+1)], 1H NMR (400 MHz, DMSO-d): δ 9.40-9.37 (m, 2H), 8.56-8.51 (m, 2H), 8.05 (s, 1H), 8.01 (t, 1H), 7.70 (d, 2H), 7.62 (d, 2H), 4.99 (d, 2H).

후처리

  1. customCompound 8 was prepared

출처 및 근거

ORD 기록
ord-49c2dd3240b64c2f8544b65165772e71
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440968B2

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