4-(4-Benzylpiperazin-1-yl)-1lambda6-thiane-1,1-dione → 1-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)piperazine

HRID 599728노트

반응식

HRID 599728 반응식
C([N:8]1[CH2:13][CH2:12][N:11]([CH:14]2[CH2:19][CH2:18][S:17](=[O:21])(=[O:20])[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[O:21]=[S:17]1(=[O:20])[CH2:16][CH2:15][CH:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH2:19][CH2:18]1

참가 물질

5

반응물 2

HCID 672737414-(4-Benzylpiperazin-1-yl)-1lambda6-thiane-1,1-dioneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 467858481-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)piperazine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A suspension of 0.57 g (1.85 mmol) 1-benzyl-4-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-piperazine and 300 mg 10% Pd/C in 30 mL MeOH was hydrogenated at 50° C. and 50 psi hydrogen pressure for 10 h. The catalyst was removed by suction filtering and the filtrate was concentrated by evaporation i. vac. The product was reacted further without purification.

후처리

  1. customwas hydrogenated at 50° C.
  2. customThe catalyst was removed by suction
  3. filtrationfiltering
  4. concentrationthe filtrate was concentrated by evaporation i
  5. customThe product was reacted further without purification

출처 및 근거

ORD 기록
ord-43f4e1a5a2ed4b30926e2096083b608d
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897603B2

반응 노트

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