4-Chloro-1-butene → HCID 11358540, 화합물

HRID 599944노트

반응식

HRID 599944 반응식
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[NH:14][N:13]=[C:12]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)[C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.[CH2:25](Cl)[CH2:26][CH:27]=[CH2:28]>>[CH2:28]([N:14]1[C:15]2[CH2:16][CH2:17][NH:8][CH2:9][CH2:10][C:11]=2[C:12]([C:18]2[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=2)=[N:13]1)[CH2:27][CH:26]=[CH2:25]

참가 물질

3

반응물 2

HCID 135654-Chloro-1-buteneHCID 672690203-(4-chloro-phenyl)-4,5,7,8-tetrahydro-1H-1,2,6-triaza-azulene-6-carboxylic acid tert-butyl ester

생성물 1

HCID 11358540HCID 11358540, 화합물수율 46.4%

실험 절차

The title compound (0.028 g) was prepared from 3-(4-chloro-phenyl)-4,5,7,8-tetrahydro-1H-1,2,6-triaza-azulene-6-carboxylic acid tert-butyl ester (Example 103, Step B; 0.2 mmol) using 1-but-3-enyl chloride (0.3 mmol) in place of 2-chloromethyl-thiophene. MS (ESI): exact mass calculated for C17H22ClN3O, 301.13. found, m/z 302.1 [M+H]+. 1H NMR (500 MHz, CDCl3): 7.40-7.37 (m, 2H), 7.31-7.28 (m, 2H), 6.75-6.67 (m, 1H), 5.02-5.00 (br m, 2H), 4.07 (t, J=7.3 Hz, 2H), 2.99-2.97 (br m, 2H), 2.91-2.89 (br m, 2H), 2.80-2.78 (br m, 2H), 2.71-2.69 (br m, 2H), 2.48 (q, J=7.3 Hz, 2H).

출처 및 근거

ORD 기록
ord-b884ea34ce2148ee8e61a71771b24b30
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897771B2

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