Sodium Sulfite → Sodium (2-methylthiazol-4-yl)methanesulfonate

HRID 60045

반응식

HRID 60045 반응식
Cl[CH2:2][C:3]1[N:4]=[C:5]([CH3:8])[S:6][CH:7]=1.[S:9]([O-:12])([O-:11])=[O:10].[Na+:13].[Na+]>O>[CH3:8][C:5]1[S:6][CH:7]=[C:3]([CH2:2][S:9]([O-:12])(=[O:11])=[O:10])[N:4]=1.[Na+:13]

참가 물질

4

반응물 2

HCID 24437Sodium SulfiteHCID 7363414-(Chloromethyl)-2-methyl-1,3-thiazole

생성물 1

HCID 59464713Sodium (2-methylthiazol-4-yl)methanesulfonate수율 101.2%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

4-Chloromethyl-2-methylthiazole (250 mg, 1.69 mmol) is dissolved in H2O (2 mL) and treated with sodium sulfite (224 mg, 1.78 mmol). The reaction mixture is subjected to microwave irradiation for 20 minutes at 200° C. The reaction mixture is diluted with H2O (30 mL) and washed with EtOAc (2×25 mL). The aqueous layer is concentrated to afford 0.368 g of the desired product as a yellow solid. LC/MS ESI+ 194 (M+1, free acid).

후처리

  1. customirradiation for 20 minutes at 200° C
  2. washwashed with EtOAc (2×25 mL)
  3. concentrationThe aqueous layer is concentrated

출처 및 근거

ORD 기록
ord-2dee5aeb32ce49538fa9567ca188082d
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440963B2

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