Ethylorthoformate → HCID 135846125, 화합물

HRID 600568노트

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[CH2:1]([N:6]1[C:14]2[N:13]=[C:12]([C:15]([F:18])([F:17])[F:16])[NH:11][C:10]=2/[C:9](=[N:19]\[NH2:20])/[NH:8][C:7]1=[O:21])[CH2:2][CH2:3][CH2:4][CH3:5].[CH:22]([O-])([O-])OCC>>[CH2:1]([N:6]1[C:14]2[N:13]=[C:12]([C:15]([F:16])([F:18])[F:17])[NH:11][C:10]=2[C:9]2=[N:19][N:20]=[CH:22][N:8]2[C:7]1=[O:21])[CH2:2][CH2:3][CH2:4][CH3:5]

참가 물질

반응물 2

HCID 53630039Ethylorthoformate

HCID 178446231HCID 178446231, 화합물

생성물 1

HCID 135846125HCID 135846125, 화합물

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온도: 100 °C

실험 절차

(6E)-3-Pentyl-8-(trifluoromethyl)-3,7-dihydro-1H-purine-2,6-dione-6-hydrazone (0.15 g, 0.20 mmol) was mixed with ethyl orthoformate (2 mL, 10 mmol). The mixture was heated at 100° C. for 30 min, concentrated under reduced pressure and purified by preparative HPLC to yield the desired product. LCMS calculated for C12H14F3N6O (M+H): 315.1. found: 315.1.

후처리

concentrationconcentrated under reduced pressure
custompurified by preparative HPLC

출처 및 근거

ORD 기록: ord-c91141feb25a484b95204e4a77158181
출처 데이터셋: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07902205B2

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