8-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-one → HCID 11964256, 화합물

HRID 600777

반응식

HRID 600777 반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][C:14]([NH:16][C:17]3[CH:18]=[CH:19][CH:20]=[C:21]4[C:26]=3[CH2:25][C:24](=[O:27])[CH2:23][CH2:22]4)=[N:13][CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].FC(F)(F)C1C=CC(C2OC(NC3C=CC=C4C=3CC(=O)CC4)=NC=2)=CC=1>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][C:14]([NH:16][C:17]3[CH:18]=[CH:19][CH:20]=[C:21]4[C:26]=3[CH2:25][CH:24]([OH:27])[CH2:23][CH2:22]4)=[N:13][CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 119558408-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-oneHCID 11964212HCID 11964212, 화합물

생성물 1

HCID 11964256HCID 11964256, 화합물

실험 절차

The title compound was prepared using the procedure of Example 2, substituting the product of Example 3B for the product of Example 1I. 1H NMR (DMSO-d6) δ 9.07 (s, 1H), 7.58 (d, 1H, J=5.4 Hz), 7.46 (m, 3H), 7.30 (s, 1H), 7.08 (t, 1H, J=7.8 Hz), 6.83 (d, 1H, J=7.1 Hz), 4.80 (d, 1H, J=4.0 Hz), 3.91 (m, 1H), 2.72-2.96 (m, 4H), 1.86 (m, 1H), 1.62 (m, 1H), 1.29 (s, 9H); MS (ESI+) m/z 363 (M+H).

출처 및 근거

ORD 기록
ord-319fcad2f74946d7b060d0374e049b3d
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902236B2

연결된 노트

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