Morpholine → 4-(6-Chloropyridine-3-carbonyl)morpholine

HRID 601001노트

반응식

HRID 601001 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][N:3]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1.C(N(CC)CC)C>ClCCl>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[O:7])=[CH:9][CH:10]=1

참가 물질

5

반응물 3

HCID 8083MorpholineHCID 8471TriethylamineHCID 27821656-Chloronicotinoyl Chloride

생성물 1

HCID 8574994-(6-Chloropyridine-3-carbonyl)morpholine수율 88%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 6-chloro-nicotinoyl chloride (0.540 g, 3.07 mmoles) in dichloromethane (10 mL) was added of morpholine, (0.294 g, 1.1 equivalents) followed by triethylamine (940 uL, 2.2 equivalents). The reaction was stirred overnight at room temperature to give (6-chloro-pyridin-3-yl)-morpholin-4-yl-methanone. No starting material, 6-Chloro-nicotinoyl chloride, remained and mass spectrometry showed correct M+ ion. An aqueous work-up was performed and the crude material was taken to the next step. The crude residue, (6-chloro-pyridin-3-yl)-morpholin-4-yl-methanone, weighed 0.610 g (88% yield) after aqueous work-up.

출처 및 근거

ORD 기록
ord-25f69ff54db3402eaf13603e76dac3fa
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902239B2

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